{"id":1724,"date":"2024-02-16T04:32:16","date_gmt":"2024-02-16T05:32:16","guid":{"rendered":"https:\/\/aaadmj.pt\/?page_id=1724"},"modified":"2024-04-27T00:03:42","modified_gmt":"2024-04-27T00:03:42","slug":"doenca","status":"publish","type":"page","link":"https:\/\/aaadmj.com\/en\/doenca\/","title":{"rendered":"The Disease"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"1724\" class=\"elementor elementor-1724\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4cfaa708 e-flex e-con-boxed e-con e-parent\" data-id=\"4cfaa708\" data-element_type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7d8b78b1 elementor-widget elementor-widget-heading\" data-id=\"7d8b78b1\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 08-05-2024 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">The Disease<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-774512ad elementor-icon-list--layout-inline elementor-laptop-align-left elementor-tablet_extra-align-center elementor-list-item-link-full_width elementor-widget elementor-widget-icon-list\" data-id=\"774512ad\" data-element_type=\"widget\" data-widget_type=\"icon-list.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<link rel=\"stylesheet\" href=\"https:\/\/aaadmj.com\/wp-content\/uploads\/elementor\/css\/custom-widget-icon-list.min.css?ver=1715656163\">\t\t<ul class=\"elementor-icon-list-items elementor-inline-items\">\n\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-inline-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/aaadmj.com\/en\">\n\n\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">Home<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t<li class=\"elementor-icon-list-item elementor-inline-item\">\n\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/aaadmj.com\/en\/doenca\/\">\n\n\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-icon\">\n\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-angle-right\" viewbox=\"0 0 256 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M224.3 273l-136 136c-9.4 9.4-24.6 9.4-33.9 0l-22.6-22.6c-9.4-9.4-9.4-24.6 0-33.9l96.4-96.4-96.4-96.4c-9.4-9.4-9.4-24.6 0-33.9L54.3 103c9.4-9.4 24.6-9.4 33.9 0l136 136c9.5 9.4 9.5 24.6.1 34z\"><\/path><\/svg>\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-icon-list-text\">The Disease<\/span>\n\t\t\t\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t<\/ul>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2b0f5ca1 e-flex e-con-boxed e-con e-parent\" data-id=\"2b0f5ca1\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-47ecfe45 e-flex e-con-boxed e-con e-child\" data-id=\"47ecfe45\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-9d1af34 e-con-full e-flex e-con e-child\" data-id=\"9d1af34\" data-element_type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-3cc5abb2 e-flex e-con-boxed e-con e-child\" data-id=\"3cc5abb2\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-11abf6f9 elementor-widget elementor-widget-heading\" data-id=\"11abf6f9\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Machado-Joseph Disease (DMJ)<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5888aefe elementor-widget elementor-widget-heading\" data-id=\"5888aefe\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h1 class=\"elementor-heading-title elementor-size-default\">To understand better, you need to know<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ebaf385 e-flex e-con-boxed e-con e-child\" data-id=\"ebaf385\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2e4b271 elementor-widget elementor-widget-image\" data-id=\"2e4b271\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 08-05-2024 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"533\" src=\"https:\/\/aaadmj.com\/wp-content\/uploads\/2024\/03\/AAADMJ-Associcao-Fotografias-Baixa-resolucao-76-1024x682.jpg\" class=\"attachment-large size-large wp-image-2349\" alt=\"\" srcset=\"https:\/\/aaadmj.com\/wp-content\/uploads\/2024\/03\/AAADMJ-Associcao-Fotografias-Baixa-resolucao-76-1024x682.jpg 1024w, https:\/\/aaadmj.com\/wp-content\/uploads\/2024\/03\/AAADMJ-Associcao-Fotografias-Baixa-resolucao-76-300x200.jpg 300w, https:\/\/aaadmj.com\/wp-content\/uploads\/2024\/03\/AAADMJ-Associcao-Fotografias-Baixa-resolucao-76-768x512.jpg 768w, https:\/\/aaadmj.com\/wp-content\/uploads\/2024\/03\/AAADMJ-Associcao-Fotografias-Baixa-resolucao-76-1536x1024.jpg 1536w, https:\/\/aaadmj.com\/wp-content\/uploads\/2024\/03\/AAADMJ-Associcao-Fotografias-Baixa-resolucao-76-18x12.jpg 18w, https:\/\/aaadmj.com\/wp-content\/uploads\/2024\/03\/AAADMJ-Associcao-Fotografias-Baixa-resolucao-76.jpg 2000w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-25ecaffd e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"25ecaffd\" data-element_type=\"container\" id=\"conceito\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7675475e e-con-full e-flex e-con e-child\" data-id=\"7675475e\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-74bb9a4d elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"74bb9a4d\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Disease definition<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2de25560 e-con-full e-flex e-con e-child\" data-id=\"2de25560\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fb3b151 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"fb3b151\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.21.0 - 08-05-2024 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p class=\" translation-block\">Machado-Joseph disease (MJD) is a neurodegenerative disease that usually manifests itself in adulthood. DMJ belongs to the group of <strong>ataxias<\/strong>, which means that the main changes present in the disease refer to the <strong>gradual loss of coordination of voluntary muscle movements and balance<\/strong>.<\/p><p class=\" translation-block\">The disease begins, therefore, in the majority of patients, <strong>by alterations in balance<\/strong>, which appear, on average, around the age of 40; there are, however, cases in which the disease appears either markedly earlier or later (6-8 years for the earliest cases and 70 years for the later ones). The <strong>clinical picture<\/strong> of the disease is considered to be very <strong>complex<\/strong>, which means that <strong>different patients can have important differences between themselves in terms of the manifestations of the disease<\/strong>.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6ad8466 e-flex e-con-boxed elementor-invisible e-con e-parent\" data-id=\"6ad8466\" data-element_type=\"container\" id=\"historia\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;animation&quot;:&quot;fadeInUp&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7224c2e elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"7224c2e\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">History<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4892fb3 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"4892fb3\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">of the Identification of DMJ: the \u2018war of the three diseases\u2019<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-971f18a elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"971f18a\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tThe history of the identification of DMJ must include a description of the three neurological diseases that were identified between 1972 and 1976 by three different groups of researchers in the United States in individuals of Azorean descent. The three new diseases, described in the Machado, Thomas and Joseph families, had common points: the patients observed were of Azorean origin and the way the disease was transmitted in the families was similar. Thus, each group of researchers believed they had discovered a different disease, maintaining their position for several years, and starting what Dr Paula Coutinho referred to as \u2018the war of the three diseases\u2019. During a visit to the Azores by Dr Paula Coutinho and Professor Corino de Andrade, these remarkable neurologists described, within the same family, patients as different as those described by the groups of researchers from the USA, thus showing that it was a single disease. In mainland Portugal, the first non-Azorean family with DMJ was described in the 1980s. In 1980, Dr Paula Coutinho and Professor Jorge Sequeiros finally proposed the name \u2018Machado-Joseph Disease\u2019, which is currently the most widely used, and which is justified by the fact that the Machado family was the first to be described, and the Joseph family constitutes the largest and best-known group of individuals.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4068b880 e-flex e-con-boxed e-con e-parent\" data-id=\"4068b880\" data-element_type=\"container\" id=\"origem\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;pyramids&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M761.9,44.1L643.1,27.2L333.8,98L0,3.8V0l1000,0v3.9\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1e8dbb3 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"1e8dbb3\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Origin of the disease<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b58f74 elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"9b58f74\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tBecause DMJ was first described in families of Azorean origin living in the United States of America, it became known as \u2018Azorean nervous system disease\u2019. It has been known for a long time that there are cases of DMJ in many parts of the world, with no connection to Portugal or the Azoreans. Thus, DMJ is not an \u2018Azorean\u2019 disease, and this fact has already been amply demonstrated in scientific papers, which point to the main origin of the alteration that leads to DMJ being Asian, which occurred several thousand years ago and then spread around the world.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d89f18f e-flex e-con-boxed e-con e-parent\" data-id=\"d89f18f\" data-element_type=\"container\" id=\"distribuicao\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;pyramids&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewbox=\"0 0 1000 100\" preserveaspectratio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M761.9,44.1L643.1,27.2L333.8,98L0,3.8V0l1000,0v3.9\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f5fb641 elementor-invisible elementor-widget elementor-widget-heading\" data-id=\"f5fb641\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Worldwide distribution of the disease<\/h3>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c8b12bc elementor-invisible elementor-widget elementor-widget-text-editor\" data-id=\"c8b12bc\" data-element_type=\"widget\" data-settings=\"{&quot;_animation&quot;:&quot;fadeInUp&quot;}\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\tDMJ is a rare disease worldwide; within its group (spinocerebellar ataxias) it is nevertheless the most common, and is present in several countries, including Brazil, the USA, Japan, China, Australia, France, Germany, the UK and the Netherlands. \n\nIn Portugal, the prevalence - i.e. the ratio between the number of patients and inhabitants - is highest in the Azores, reaching its highest value on the island of Flores.\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>A doen\u00e7a de Machado-Joseph (DMJ) \u00e9 uma doen\u00e7a neurodegenerativa que se manifesta habitualmente na vida adulta.<\/p>","protected":false},"author":1,"featured_media":2857,"parent":0,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1724","page","type-page","status-publish","has-post-thumbnail","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.6 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>A Doen\u00e7a - AAADMJ - Associa\u00e7\u00e3o Atl\u00e2ntica de Apoio aos Doentes de Machado-Joseph<\/title>\n<meta name=\"description\" content=\"A doen\u00e7a de Machado-Joseph (DMJ) \u00e9 uma doen\u00e7a neurodegenerativa que se manifesta habitualmente na vida adulta.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/aaadmj.com\/en\/doenca\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A Doen\u00e7a - 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